The Neuron Imaging & Calcium Channels Team

Happy 2021!

 

Our team in January 2021 

From left to right: Myrto Freskou (university internship), Laila Blömer (PhD student), Luiza Filipis (postdoc) and Marco Canepari.

Optical measurement of sodium currents in the axon initial segment

The action potential is the fundamental signal of neuronal cells. In mammalian neurons, this signal is generated in the initial segment of the axon by a fast sodium current mediated by voltage-gated sodium channels. We developed a unique method allowing the measurement of the sodium current in the axon initial segment during the action potential generation. This novel technique opens the gate to the full understanding of neuronal excitation and to the investigation of genetic diseases caused by neuronal excitability dysfunction.

Optical measurement of physiological sodium currents in the axon initial segment.

Filipis L, Canepari M. J Physiol 599: 49-66, 2021 doi: 10.1113/JP280554.

Jobs and studentships

Candidates wishing to work with us and eligible for EU Marie Curie fellowships, French govements studentships and/or other types of individual fundings are encoraged to contact us any time of the year.

News

01/01/2021:

Optical measurement of physiological sodium currents in the axon initial segment: our paper is now published in the

Journal of Physiology:

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280554

26/02/2020:

The origin of physiological local mGluR1 supralinear Ca2+ signals in cerebellar Purkinje neurons: our paper is now published in the Journal of Neuroscience:

https://www.jneurosci.org/content/40/9/1795

19/12/2019:

Congratulations Luiza, you are Doctor! Luiza Filipis discussed her thesis entitled "Optical and computational study of the function of neuronal ion channels" and she obtained her PhD. 

01/09/2019:

Welcome Laila! Laila Blömer started her PhD and she will work on photoactivable toxins and applications to investigate ion channels in layer-5 neocortical pyramidal neurons. 

13/03/2019:

The parallel dynamics of multiple ion channels revealed by combined imaging techniques and computational methods: our first paper is now published in the Journal of Neuroscience:

http://www.jneurosci.org.gate2.inist.fr/content/39/11/1969.long

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