The Neuron Imaging & Calcium Channels Team
Our team in January 2021
From left to right: Myrto Freskou (university internship), Laila Blömer (PhD student), Luiza Filipis (postdoc) and Marco Canepari.
Optical measurement of sodium currents in the axon initial segment
The action potential is the fundamental signal of neuronal cells. In mammalian neurons, this signal is generated in the initial segment of the axon by a fast sodium current mediated by voltage-gated sodium channels. We developed a unique method allowing the measurement of the sodium current in the axon initial segment during the action potential generation. This novel technique opens the gate to the full understanding of neuronal excitation and to the investigation of genetic diseases caused by neuronal excitability dysfunction.
Filipis L, Canepari M. J Physiol 599: 49-66, 2021 doi: 10.1113/JP280554.
Candidates wishing to work with us and eligible for EU Marie Curie fellowships, French govements studentships and/or other types of individual fundings are encoraged to contact us any time of the year.
Optical measurement of physiological sodium currents in the axon initial segment: our paper is now published in the
Journal of Physiology:
The origin of physiological local mGluR1 supralinear Ca2+ signals in cerebellar Purkinje neurons: our paper is now published in the Journal of Neuroscience:
Congratulations Luiza, you are Doctor! Luiza Filipis discussed her thesis entitled "Optical and computational study of the function of neuronal ion channels" and she obtained her PhD.
Welcome Laila! Laila Blömer started her PhD and she will work on photoactivable toxins and applications to investigate ion channels in layer-5 neocortical pyramidal neurons.
The parallel dynamics of multiple ion channels revealed by combined imaging techniques and computational methods: our first paper is now published in the Journal of Neuroscience: